CORE LABORATORY
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COAGULATION METHODOLOGIES AND APPLICATIONS

Optical and Mechanical Clot Detection Methodologies

Two common clot detection methodologies. While the optical methods detects clots by measuring changes in the optical density of a test sample, the mechanical method involves the monitoring of a steel ball within the test solution using a magnetic sensor. A comparative analysis on the advantages and disadvantages will be reviewed.

Chromogenic Methodologies

The use of chromogenic substrate methods in coagulation and fibrinolysis diagnostics are now well established for several analytes such as antithrombin, FVIII, protein C, plasminogen, plasmin inhibitor, heparins, and pentasaccharides.

Immunoturbidimetric Methodologies

Immunoturbidimetric methods that have become the main technique for performing specific protein tests. Immunoturbidimetric technique measures turbidity of a sample to determine the concentration of an analyte.

Aggregation Methodologies

Aggregation uses principals of light scatter over multiple points in time to detect changes in a sample after an antagonist reagent is added to cause a reaction in the plasma.