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Neutrophilic Leukocytosis

Overview

Neutrophilia refers to a higher than normal number of neutrophils. Neutrophilia may result from a shift of cells from the marginal to the circulating pool (shift neutrophilia) without an increase in the total blood granulocyte pool (TBGP) or from a true increase in TBGP size (true neutrophilia).1

 

During established infection, the neutrophil count remains elevated, with equal numbers in the marginal and the circulating pool. During the recovery phase, the flow of cells from the marrow decreases, with a resultant decrease in the number of neutrophils.1

 

The adequate production and distribution of normally functioning neutrophils is vital to host defense. During an infection, chemotactic agents are generated that attract neutrophils to the site of infection, which in turn play a critical role in phagocytosing and killing microorganisms.1

 

Symptoms
  • Signs of infection (such as fever, cough, or abdominal pain),
  • Signs of chronic illness (such as weight loss or fatigue).2

 

Causes

The most common cause of an increased number of neutrophils is the normal response of the body to an infection. In many instances, the increased number of neutrophils is a necessary reaction by the body, as it tries to heal or ward off an invading microorganism or foreign substance. Infections by bacteria, viruses, fungi, and parasites may all increase the number of neutrophils in the blood.2

FEATURED CASES

FEATURED CASE
Platelet Clumps | Alinity hq
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FEATURED CASE
Leukocytosis With Left Shift And Immature Granulocytes (IG), And Macrocytosis | Alinity hq
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FEATURED CASE
Chronic Myelocytic Leukemia | Alinity hq
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Granulocytosis | CELL-DYN Ruby
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Left Shift of Granulopoiesis with IG Flag | CELL-DYN Ruby
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Immature Granulocytes (IG) | CELL-DYN Ruby
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1. Medscape. Neutrophilia. https://emedicine.medscape.com/article/208576-overview
2. Merck Manual. Neutrophilic Leukocytosis. https://www.merckmanuals.com/home/blood-disorders/white-blood-cell-disorders/neutrophilic-leukocytosis
Image source: Cancer Therapy Advisor https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/hematology/leukocytosis-2/

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Alinity h-series is available in select countries, not including the US.