Disorders of Platelet Adhesion and Aggregation classify as Platelet Function Disorders.
Platelet adhesion to blood vessel walls is one of the crucial physiological events in thrombosis and hemostasis. An adhesion disorder is the result of the platelets not being able to stick to the wall of the damaged blood vessel to form a plug and stop the bleeding.1
An aggregation disorder is when platelets do not bind with fibrinogen and other proteins in order to stick to other platelets. As a result the platelets cannot form a plug to stop the bleeding from a damaged blood vessel.1
There are Acquired platelet function disorders as well as Hereditary platelet function disorders.
Hereditary platelet function disorders include:2
Symptoms of the Acquired platelet function disorders vary and they can include:3
Symptoms of Hereditary platelet function disorders may include purpura, petechiae, prolonged bleeding from cuts, epistaxis, gum bleeding, excessive bleeding after surgery, hemoptysis, hematuria, and menorrhagia in women.4
Acquired platelet function disorders have three main causes — medications, diseases, and foods. They can also be caused by supplements.3
Inherited platelet function disorders are autosomal recessive disorders caused by mutations in genes.4