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Disorders of Platelet Adhesion and Aggregation

Overview

Disorders of Platelet Adhesion and Aggregation classify as Platelet Function Disorders.

 

Platelet adhesion to blood vessel walls is one of the crucial physiological events in thrombosis and hemostasis. An adhesion disorder is the result of the platelets not being able to stick to the wall of the damaged blood vessel to form a plug and stop the bleeding.1

 

An aggregation disorder is when platelets do not bind with fibrinogen and other proteins in order to stick to other platelets. As a result the platelets cannot form a plug to stop the bleeding from a damaged blood vessel.1

 

There are Acquired platelet function disorders as well as Hereditary platelet function disorders.

 

Hereditary platelet function disorders include:2

 

  • Bernard–Soulier syndrome
  • von Willebrand disease
  • Glanzmann Thrombasthenia2
Symptoms:

Symptoms of the Acquired platelet function disorders vary and they can include:3

 

  • unexplained bruising throughout the body
  • bleeding from the nose, mouth, or gums
  • heavy or prolonged menstrual bleeding
  • bleeding under the skin
  • bleeding into the muscles and joints
  • blood in the vomit or feces
  • internal bleeding
  • small red bumps on the skin (petechiae)3

 

Symptoms of Hereditary platelet function disorders may include purpura, petechiae, prolonged bleeding from cuts, epistaxis, gum bleeding, excessive bleeding after surgery, hemoptysis, hematuria, and menorrhagia in women.4

Causes and Risk Factors

Acquired platelet function disorders have three main causes — medications, diseases, and foods. They can also be caused by supplements.3

 

Inherited platelet function disorders are autosomal recessive disorders caused by mutations in genes.4

FEATURED CASES

FEATURED CASE
Platelet Satellites | CELL-DYN Ruby
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FEATURED CASE
NWBC Flag (Pseudo-thrombocytopenia) | CELL-DYN Ruby
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FEATURED CASE
Platelet Aggregation | CELL-DYN Ruby
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FEATURED CASE
Platelet Satellitism | CELL-DYN Ruby
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1. Platelet Disorders. https://www.chla.org/platelet-disorders
2. Inherited bleeding disorders: disorders of platelet adhesion and aggregation. https://www.sciencedirect.com/science/article/abs/pii/S1040842803001173
3. Acquired Platelet Function Disorder. https://www.healthline.com/health/acquired-platelet-function-defect#symptoms
4. Diagnostic considerations with inherited platelet disorder testing. https://www.mlo-online.com/continuing-education/article/13009439/diagnostic-considerations-with-inherited-platelet-disorder-testing
Image source: Science Direct. Thrombosis Research. https://www.sciencedirect.com/science/article/pii/S0049384815300876
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