Scott syndrome is an inherited bleeding disorder characterized by the loss of the capacity of platelets to externalize phosphatidylserine. Platelet count, size, adhesion, and aggregation activities are normal. The impaired binding of activated factor V and factor VIII results in diminished thrombin generation. Mutations of a transmembrane protein (TMEM)-16F were described in 2 patients with Scott syndrome.1,2
This condition is inherited in an autosomal recessive manner.