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Acute Leukemia


The sample shows all the features of a high-grade malignancy such as lymphoblastic lymphoma or acute leukaemia. There is an increased WBC count, a marked neutropenia and severe thrombocytopenia, and an anaemia that is slightly macrocytic. The graphical WBC displays essentially show a single population cluster with moderate size variability and evidence of WBC fragility (FWBC flag).


Although the predominant population is nominally classified as lymphoid, it is possible for blast cells in the more immature (agranular) acute myeloid leukaemias to show similar optical characteristics. It is also not uncommon for the abnormal cells in acute leukaemias to show abnormally increased osmotic fragility (FWBC).


Finally, the LURI flag indicates the presence of both lower and upper range interferences in the platelet count. This is a relatively common feature in some high-grade proliferations that have circulating cell fragments or abnormal plasma components.

Numerical Results

WBC 38.4 10e3/μL   WBC
NEU .460 1.20 %
LYM 37.2 96.9 % VARLYM
MONe .317 .825 %  FWBC
EOS .004 .010 %
BASO .398 1.04 % DFLT (NLMEB)

RBC 2.11 10e6/μL
HGB 7.27 g/dL
HCT 22.0 %
MCH 34.4 pg
MCHC 33.0 g/dL
RDW 17.7 %

PLT 15.2 10e3/μL
MPV 11.5 fL  LURI

CELL-DYN Ruby Casebook. Acute Leukemia. 2018. ADD-00005070. p.42
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