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Alinity hq

Eosinophilia

Description

This patient presented with a normal white blood cell (WBC) count and slightly decreased hemoglobin and platelet count. The most notable finding was marked eosinophilia.

 

A manual differential was performed, which revealed 48% neutrophils, 13% lymphocytes, 9% monocytes and 30% eosinophils. Red blood cell (RBC) and platelet (PLT) morphology appeared normal.

 

An increased eosinophil count is usually associated with allergy, parasitic infection, and certain autoimmune and myeloproliferative diseases, where sustained eosinophilia may result in organ damage (Gotlib).

Numerical Results

 
WBC 7.17 10e3/μL
NEU 3.16 10e3/μL 44.1 %
LYM 1.20 10e3/μL 16.7 %
MONO 0.53 10e3/μL 7.40 %
EOS 2.25 10e3/μL 31.4 %
BASO .024 10e3/μL .342 %
IG 0.01 10e3/μL .015 %
NRBC 0.00 10e3/μL
NR/W 0.00

 
RBC 3.40 10e6/μL
HGB 11.6 g/dL
HCT 33.6 %
MCV 98.5 fL
MCH 34.0 pg
MCHC 34.6 g/dL
RDW 17.5 %

 
RETIC 130. 10e3/μL 3.84 %
IRF .363
MCHr 33.0 pg

 
PLT 138. 10e3/μL
MPV 7.07 fL
%rP 5.38 %

 
FIGURE 1. IAS x ALL (WBC):
Intermediate angle light scatter vs. size plot
Eosinophils (green), which are usually present in small numbers, appear as a large population on this plot, directly underneath the neutrophil cluster (yellow).
FIGURE 2. PSS x DSS (WBC):
Polarized side scatter vs. depolarized side scatter
Neutrophils (yellow) are differentiated from eosinophils (green) in this scatterplot. Eosinophils have a much higher DSS than neutrophils, allowing a dynamic threshold to separate them. The large crystalline secondary granules in eosinophils are responsible for their increased DSS.
Alinity hq Casebook. Eosinophilia. ADD-00061876-v2; 2019. p.36-37

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Alinity h-series is available in select countries, not including the US.