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Mantle Cell Lymphoma


This 60 year old male patient was referred by his general practitioner to a specialist because of persisting lymphadenopathy. The peripheral blood count on CELL-DYN Ruby showed thrombocytopenia and leukocytosis which was accompanied by the DFLT (LM) flag, indicating that the algorithm was unable to make a clear separation between the lymphocyte and monocyte population. Visual interpretation of the WBC scatterplots and the NWBC-LYM-MONO histogram suggested that the default threshold lines spuriously classified part of the “lymphocyte” population as monocytes. This finding was confirmed by microscopic examination, which showed mainly medium-sized pleomorphic lymphocytes with irregular nuclei. Immunological typing of the leukemic cells and lymph nodes confirmed the diagnosis of mantle cell lymphoma.

Numerical Results

WBC 16.7 10e3/μL   NOC
NEU 4.08 24.4 %
LYM 10.3* 61.6* % VARLYM
MONO 2.03* 12.2* %
EOS .201 1.20 %
BASO .102* .611 % DFLT (LM)

RBC 4.23 10e6/μL
HGB 12.5 g/dL
HCT 39.2 %
MCV 92.6 fL
MCH 29.5 pg
MCHC 31.9 g/dL
RDW 13.9 %

PLT 98.2 10e3/μL
MPV 12.7 fL

CELL-DYN Ruby Casebook. Mantle Cell Lymphoma. 2018. ADD-00005070. p.41
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