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Myelodysplastic Syndrome (MDS RAEB)


This sample was from a patient who was regularly monitored since myelodysplastic syndrome (MDS) had been diagnosed previously. The hemogram showed pancytopenia: neutropenia, normocytic normochromic anemia and thrombocytopenia. Typically this disease is characterized by two-or three-lineage cytopenia with dysplastic features in one or more cell lines. The SIZE/ COMPLEXITY scatterplot displayed a cluster of large granulocytes, triggering the BAND flag. Notable was also the quite low lobularity of the neutrophils in the GRANULARITY/ LOBULARITY and the 90º/WBC 0º plots. The scatterplots showed no signs of abnormal granulation, but manual microscopy demonstrated hypogranulation and dysplastic features in almost all granulocytes. Also immature granulocytes were observed as well as 5% blast cells. All these findings are well compatible with the MDS diagnosis.

Numerical Results

WBC 2.12 10e3/μL
NEU .969 45.79 %  BAND
BLST .031 1.45 %
MONe .333 15.7 %
EOS .022 1.04 %
BASO .072 3.39 %
LYM .692 32.68 % BLAST

RBC 3.69 10e6/μL
HGB 10.0 g/dL
HCT 30.2 %
MCV 81.8 fL
MCH 27.2 pg
MCHC 33.2 g/dL
RDW 15.4 %

PLT 65.2 10e3/μL
MPV 10.3 fL

CELL-DYN Ruby Casebook. Myelodysplastic Syndrome (MDS RAEB). 2018. ADD-00005070. p.44
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