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Significance of Mean Cell Hemoglobin of the Reticulocytes (MCHr) biomarker in Diagnosis of Iron Deficiency Anemia

Overview

Iron is an essential metal for the body and is required for hemoglobin synthesis in erythrocytes, oxidation reduction reactions & cellular proliferation. Iron deficiency anemia (IDA) is the most common anemia worldwide. It is especially prevalent in women and children in regions where meat intake is low, food is not fortified with iron, and where malaria and other parasitic infections are common. The analysis of Mean Cell Hemoglobin of the reticulocytes (MCHr) by a hematology analyzer can help monitor acute changes in hemoglobin incorporation into the erythron and is more sensitive than indirect chemical methods. Compared with erythrocytes, the shorter lifespan of reticulocytes makes MCHr a better biomarker to reflect short term iron status in patients than hemoglobin values. Since MCHr values can be obtained on a routine CBC, it is an attractive alternative for the diagnosis of IDA, especially in countries with high prevalence of the disease.

 

Speaker

Dr. Nita Munshi, MD
Professor, Head and Director of Laboratory, Ruby Hall Group of Hospitals
(Pune, India)

 

Objectives
  • Review the global impact of iron deficiency anemia (IDA)
  • Describe iron metabolism, absorption, regulation, and storage
  • Review laboratory diagnosis of IDA, including new parameters
  • Share results of IDA study performed on Abbott’s Alinity hq CBC analyzer

 

Note: Alinity hq is available in select countries, not including the US.

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CONTRIBUTORS

Contributor
Dr. Nita Munshi
BIO
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