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Platelets are cell fragments that circulate in the bloodstream and help blood clot. Platelet disorders include an abnormal increase in platelets (essential thrombocythemia and reactive thrombocytosis), a decrease in platelets (thrombocytopenia) and a platelet dysfunction.1

 

Any of these conditions, even those in which platelets are increased, may cause defective formation of hemostatic plugs and bleeding. The risk of bleeding is inversely proportional to the platelet count and platelet function. When platelet function is reduced (eg, as a result of uremia or aspirin use), the risk of bleeding increases.1

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