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Coagulation Disorders

Coagulations disorders are conditions that affect the blood’s clotting activities. Coagulation disorders can result in either a hemorrhage (too little clotting that causes an increased risk of bleeding) or thrombosis (too much clotting that causes blood clots to obstruct blood flow). Hemophilia, Von Willebrand disease, clotting factor deficiencies, hypercoagulable states and deep venous thrombosis are all coagulations disorders. Hemophilia and Von Willebrand disease are among the best known.1

Hemophilia

Hemophilia is an inherited bleeding disorder in which a person lacks or has low levels of certain proteins called “clotting factors” and the blood doesn’t clot properly as a result. This leads to excessive bleeding. According to the World Federation of Hemophilia (WFH), about one in 10,000 people are born with this disease.
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Von Willebrand Disease

Von Willebrand disease (VWD) is a genetic disorder caused by missing or defective von Willebrand factor (VWF), a clotting protein. VWF binds factor VIII, a key clotting protein, and platelets in blood vessel walls, which help form a platelet plug during the clotting process.
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Clotting Factor Deficiences

Rare clotting factor deficiencies are a group of inherited bleeding disorders caused by a problem with one or several clotting factors. Clotting factors are proteins in the blood that control bleeding.
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Deep Vein Thrombosis

Deep vein thrombosis occurs when a blood clot forms in a major vein, usually in the leg. This blood clot stops blood from flowing easily through the vein, which can lead to swelling, discoloration, and pain in the leg.
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Hypercoagulable States

A hypercoagulable state is the medical term for a condition in which there is an abnormally increased tendency toward blood clotting (coagulation).
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1. John Hopkins Medicine. Coagulation Disorders. https://www.hopkinsmedicine.org/health/conditions-and-diseases/coagulation-disorders
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